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KMID : 0614619940260040631
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Korean Journal of Gastroenterology
1994 Volume.26 No. 4 p.631 ~ p.636
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Evaluation of Serological Diagnosis for Helicobacter pylori Infection
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이우진
김재규/김용태/최상운/정현채/송이성/최규완/김정룡
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Abstract
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To evaluate the efficacy of serologic test in diagnosis of Helicobacter pylori infection, ELISA was used to detect IgG antibody against partially purified H. pylori outer membrane antigen (Bio-RAD GAP test IgG). Endoscopic gastric antral biopsy
specimens were also obtained for microscopic examination of the bacteria and rapid urease test (CLO test). Eighty one patients (47 nonulcer dyspepsia patients, 11 benign gastric ulcer patients and 23 duodenal ulcer patients) were enrolled in this
study.
Detection of H. pylori by microscopy was considered as true positive for H. pylori infection. Abscence of H. pylori by microscopy and positive CLO test was considereed as equivocal and these cases were excluded in the analysis of the data. H.
pylori
infections were detected in 58 (77%) of 81 patients, 30(64%) of 47 nonulcer dyspepsia patients, 9(82%) of 11 benign gastric lucer patients and 19(83%) of 23 duodenal ulcer patients). Nineteen of 81 were negative and 4 of 81 were equivocal in H.
pylori
infection. The sensitivity of the serologic test was 72% and the specificity was 53% In conclusion, the sensitivity and specificity of the serologic test for diagnosis of H. pylori infection is very low, they must be improved to be used
clinically.
(Korean J Gastroenterol 1994 ; 26 : 631-636)
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